Why does the exposure route matter, and what's the risk? 

1. What is titanium dioxide?

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The realization of neuromorphic resistive memory in TiO₂ thin films (Strukov et al., 2008) marked an important milestone in the search for bio-inspired technologies (Chua and Kang, 1976). Many research proposals urged a focus on memristivity as the common feature of two electrical models: (i) electromigration of point defects in titanium oxide systems (Baiatu et al., 1990; Jameson et al., 2007) and (ii) voltage-gated ionic channels in the membranes of biological neurons (Hodgkin and Huxley, 1952). In this regard, memristors functionally mimic the synaptic plasticity of biological neurons, and thus can be implemented in artificial and hybrid neural networks. This includes a new paradigm of future computing systems (Zidan, 2018) and biocompatible electronics such as biointerfaces and biohybrid systems (Chiolerio et al., 2017).

The use of titanium dioxide (TiO2) in factory settings is widespread, with this versatile compound playing a crucial role in various industrial processes. TiO2 is a naturally occurring mineral that is widely used as a white pigment in paints, coatings, plastics, paper, and other products. Its ability to effectively scatter light makes it an ideal choice for creating bright, durable, and long-lasting finishes.

In a 2019 study published in the journal Nanotoxicology, researchers recreated the first phase of digestion in mice and fed them titanium dioxide, then examined whether accumulation occurred in the organs. Researchers wrote: “Significant accumulation of titanium was observed in the liver and intestine of E171-fed mice; in the latter a threefold increase in the number of TiO2 particles was also measured. Titanium accumulation in the liver was associated with necroinflammatory foci containing tissue monocytes/macrophages. Three days after the last dose, increased superoxide production and inflammation were observed in the stomach and intestine. Overall, [this] indicates that the risk for human health associated with dietary exposure to E171 needs to be carefully considered.”

Tioxide process. This process is similar to that used to produce fumed silicas. Ultra-low particle size titanium dioxide (15-35 nm) is obtained for use as photocatalyst or UV absorber (for instance in sun protective creams).