Authors like to thank Sebastián García (LAMARX) for spectra acquisition, Carolina Leimbruguer for her support with TEM images and Yanina Altamirano, Nicolas Jaime and Javier Reparaz for animal care assistance.

Europe

Chloride process. This process requires a high titanium feedstock. Rutile is reacted with hydrochloric acid to produce titanium tetrachloride, which can be hydrolyzed with steam or oxidized with air to render the dioxide. A rutile form of titanium dioxide is obtained.

Barium sulfide is produced by carbothermic reduction of barium sulfate. Zinc sulfate is obtained from a variety of zinc products, often waste, by treatment with sulfuric acid.

Duan et al. administered 125 mg/kg BW or 250 mg/kg BW of anatase TiO₂ (5 nm) intragastrically to mice continuously for 30 days. The exposed mice lost body weight, whereas the relative liver, kidney, spleen and thymus weights increased. Particles seriously affected the haemostasis of the blood and the immune system. The decrease in the immune response could be the result of damage to the spleen, which is the largest immune organ in animals and plays an important role in the immune response. Powel et al. demonstrated that TiO₂ NPs may trigger immune reactions of the intestine after oral intake. They showed that TiO₂ NPs conjugated with bacterial lipopolysaccharide, but not TiO₂ NPs or lipopolysaccharide alone, trigger the immune response in human peripheral blood mononuclear cells and in isolated intestinal tissue. This indicates that TiO₂ NPs may be important mediators in overcoming normal gut-cell hyporesponsiveness to endogenous luminal molecules, which may be particularly relevant to patients with inflammatory bowel disease, which is characterized by an abnormal intestinal permeability.

Overall, TiO2 powder suppliers play a vital role in ensuring that industries have access to the high-quality TiO2 powder they need for their various applications. By sourcing and supplying this essential raw material, TiO2 powder suppliers help to drive innovation and growth in industries around the world.

Rebecca Capua is an assistant conservator in the Paper Conservation Department at the Metropolitan Museum of Art since 2009. She received an MA in art history and an Advanced Certificate in art conservation from the Conservation Center, Institute of Fine Arts, New York University in 2007. Her primary area of research is on the materials of American artists of the late 19th and early 20th century. Address: The Sherman Fairchild Center for the Conservation of Works on Paper, Metropolitan Museum of Art, 1000 Fifth Avenue, New York, NY 10028. Email: rebecca.capua@metmuseum.org.

Lithopone 30% CAS No. 1345-05-7 / Physical data

In order to contribute with experimental evidence that could help to achieve a better understanding of the field for future regulation, in the present work, the biocompatibility of commercial P25TiO₂NPs (one type of TiO₂NPs used in sunscreen formulations) and two novel functionalized P25TiO₂NPs were evaluated under solar simulated irradiation. White light, generated by red, blue, and yellow LEDs, together with UV ones, was chosen to simulate the solar spectra. Functionalization of TiO₂NPs was made with antioxidant vitamins in order to prevent the expected photo-initiated ROS production when nanoparticles are exposed to the simulated solar spectra. Vitamin B2 (riboflavin) and vitamin C were chosen to carry out the functionalization because they are water-soluble, low-cost, and are a constitutive part of biological processes. In addition, it is known that both have the potential to prevent macromolecular oxidation by ROS [23], [24], [25], [26].

3. What is EFSA saying in its 2021 opinion on the safety of titanium dioxide as a food additive?

Blanc de lithopone, blanc de Comines, zincolith, blanc de Charlton, blanc de Becton, tithopone

Titanium dioxide, or TiO2, sometimes referred to as E171, is an inorganic, solid substance used in a wide range of consumer goods including cosmetics, paint, plastic and food, according to the American Chemistry Council.

Lithopone is the re-discovered white pigment with functional properties suitable for several applications.

Preparation of Lithopone: