- Manufacturers of Lithopone B301 play a crucial role in the supply chain of this important pigment. These manufacturers are responsible for producing high-quality Lithopone B301 that meets the strict specifications and requirements of their customers. They must ensure that the pigment is of consistent quality, free from impurities, and meets the necessary regulatory standards.
One of the key players in the titanium dioxide manufacturing industry is CAS 13463-67-7. This factory is known for its high-quality products and state-of-the-art facilities. With a focus on innovation and sustainability, CAS 13463-67-7 has become a go-to choice for companies looking to source titanium dioxide for their dyes and pigments.
R-895 is a paint grade titanium dioxide pigment produced by the chlorination process. Recommended for use in a variety of coating applications.

Various titanium-rich minerals, including ilmenite and rutile, can serve as starting materials for the production of highly purified Titanium Dioxide. The predominant method employed in Titanium Dioxide production is the chloride process. In this process, the mineral, along with coke and chlorine, undergoes a reaction within a fluidized bed, resulting in the formation of primarily titanium tetrachloride and carbon dioxide. Subsequently, the titanium tetrachloride undergoes purification and conversion to Titanium Dioxide. Another method involves treating ilmenite with sulfuric acid to manufacture the chemical.
Titanium dioxide, (TiO2), a white, opaque, naturally occurring mineral existing in a number of crystalline forms, the most important of which are rutile and anatase. These naturally occurring oxide forms can be mined and serve as a source for commercial titanium. Titanium dioxide is odourless and absorbent. Its most important function in powder form is as a widely used pigment for lending whiteness and opacity.
No acute effects of nano-sized TiO2 were observed in Danio rerio (zebrafish) embryos. Exposure of rainbow trout to TiO2 NPs triggered lipid peroxidation, influence on the respiratory tract, disturbance in the metabolism of Cu and Zn, induction of intestinal erosion and accumulation in kidney tissue. Linhua et al. exposed juvenile carp to 100 and 200 mg/ml of particles and TiO2 observed no mortality. However, the fish suffered from oxidative stress and pathological changes in gill and liver. In the infaunal species Arenicola marina, exposure to TiO2 NPs in sediment caused sub-lethal effects including decrease in casting rate and increase in cellular and DNA damage. Aggregated particles were visible in the lumen of the gut, but no uptake through the gut or the skin was observed.
Lithopone, a white pigment composed of a mixture of barium sulfate and zinc sulfide, is commonly used in the leather industry as a coloring agent. Leather suppliers around the world rely on lithopone to achieve the desired color and finish on their products.
In order to evaluate the penetration of the nanoparticles, eight adult male Wistar rats (3 months old) were used for the in vivo experiments. The protocol was approved by the local University Committee for animal testing and is in accordance with the Canadian Council on Animal Care (CICUAL-RD-2021–892-E-UNC-DEC#FCQ).
JECFA also evaluated estimates of dietary exposure to titanium dioxide, estimating the maximum 95th percentile of exposure to be 10 mg/kg BW per day. Overall, considering the low oral absorption of titanium dioxide as a food additive, the committee reaffirmed the ADI “not specified” that was established at the 13th meeting.
It turns into light gray after being exposed to ultraviolet rays in sunlight for 6 to 7 hours, but it will return to its original color when placed in a dark place. It is easy to oxidize in the air and then agglomerate and deteriorate when exposed to moisture.
Lithopone B301, Lithopone B311 powder is white powder, non-toxic, odorless, insoluble in water, no reaction with H2S and lye, release H2S gas when reacting with strong acids.

Dispersion in the polymer: optimum dispersion should produce a good distribution and separation of titanium dioxide particles in the formulation.
THE OBSCURE HISTORY OF A UBIQUITOUS PIGMENT: PHOSPHORESCENT LITHOPONE AND ITS APPEARANCE ON DRAWINGS BY JOHN LA FARGE
Lithopone 30% CAS No. 1345-05-7 / Application
In its statement to USA TODAY, the FDA maintained that, in all post-approvals for food additives, our scientists continue to review relevant new information to determine whether there are safety questions and whether the use of such substance is no longer safe under the Federal Food, Drug, and Cosmetic Act.
Regarding flavoring substances, JECFA concluded that there is no safety concern and established specifications for 21 agents across three classes: aliphatic primary alcohols, aldehydes, carboxylic acids, acetals, and esters containing additional oxygenated functional groups; linear and branched-chain aliphatic, unsaturated and unconjugated alcohols, aldehydes, acids, and related esters; and saturated aliphatic acyclic linear primary alcohols, aldehydes, and acids.


What does titanium dioxide do?
In food, titanium dioxide has a few different uses. Most notably, its food-grade form is used as a colorant to enhance and brighten the color of white foods such as dairy products, candy, frosting, and the powder on donuts. For foods that are sensitive to UV light, titanium dioxide is used for food safety purposes to prevent spoilage and increase the shelf life of food.
In a 2019 study published in the journal Nanotoxicology, researchers recreated the first phase of digestion in mice and fed them titanium dioxide, then examined whether accumulation occurred in the organs. Researchers wrote: “Significant accumulation of titanium was observed in the liver and intestine of E171-fed mice; in the latter a threefold increase in the number of TiO2 particles was also measured. Titanium accumulation in the liver was associated with necroinflammatory foci containing tissue monocytes/macrophages. Three days after the last dose, increased superoxide production and inflammation were observed in the stomach and intestine. Overall, [this] indicates that the risk for human health associated with dietary exposure to E171 needs to be carefully considered.”