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Although the study did not show a drop in markers of the inflammatory response in the blood, the results are thought to be due to inflammatory proteins present in joint space. One of the studies showed joint pain eased in two hours with a curcurin supplement and one hour with a nonsteroidal inflammatory response drug, ibuprofen, a drug recommended for joint problems. The duration of curcumin supplementation was 4 to 12 weeks.
Therefore, after curcumin is ingested in the body, it is difficult for the gastrointestinal tract to absorb, metabolize and quickly remove from the body. Consuming curcumin in foods rich in lecithin, such as eggs, vegetable oil, and buttermilk, may help increase its absorption through the gut. Studies combining curcumin with piperine, the natural ingredient of black pepper, have shown that because piperine slows the metabolism of curcumin, it increases curcumin levels by a factor of 20.