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In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

What is the FDA limit for titanium dioxide?

Cosmetics manufacturers utilize titanium dioxide for its ability to provide sun protection and enhance the appearance of skincare products. As a physical sunscreen, TiO2 effectively blocks harmful UV rays, preventing skin damage and reducing the risk of skin cancer. Additionally, its natural white color adds luminosity to makeup and other beauty products, making them more appealing to consumers.
China’s TiO2 exports were booming in 2016. The continuously depreciating RMB and the increasing export scales of China’s manufacturers have strengthened this development throughout the year. As a fact, many of China’s producers exported their products with a lower price while achieving higher profit margins in the domestic market of TiO2. Tranalysis, a trade analysis provider, now reveals the top 10 Chinese TiO2 exporters of the year 2016 with the original data of China Customs.
Titanium dioxide (TiO2) is a widely used substance in various industries, including plastic manufacturing. It is known for its exceptional properties that make it an ideal additive in the production of plastics. In this article, we will explore the use of TiO2 in plastic manufacturers and its benefits.
Titanium dioxide (E 171) is authorised as a food additive in the EU according to Annex II of Regulation (EC) No 1333/2008.
Company C, a pioneer in the pigment industry, boasts a wide range of Lithopone products, including the B301 and B311 grades. With state-of-the-art manufacturing facilities and strict quality control measures, they guarantee premium quality products that consistently deliver outstanding performance.
A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”
Blanc de Comines, 27 per cent zinc sulphide, 70.5 per cent barium sulphate, 2.5 per cent zinc carbonate.
The first step in the process is the grinding of the ore to a fine powder. This powder is then mixed with chlorine and sulfuric acid in a reactor to form titanium tetrachloride (TiCl4). This compound is a key intermediate in the production of titanium dioxide.

The process of manufacturing titanium dioxide begins with the extraction of titanium ore, such as rutile or ilmenite, from the ground. The ore is then processed to remove impurities and other minerals, leaving behind a pure form of titanium dioxide. This pure form is then further processed through various chemical reactions to create the final pigment.

Titanium dioxide is found in pretty much all makeup & sunscreen.

And studies have long shown that products applied to the skin end up in the bloodstream within half an hour. With penetration rates depending on where they are applied. Absorption rates for your face & scalp are 5-10 times higher than on other parts of our body (Hotchkiss 1994).

Not to mention that in 2005, the Environmental Working Group published a combination of two studies that found toxic chemicals in the umbilical cord blood of newborn babies born in the U.S. They screened for more than 400 chemicals, and an astounding 287 toxins were detected within the umbilical cord blood of these newborns. Of these 287 chemicals, 217 were neurotoxins, and 208 are known to damage growth development or cause birth defects.
The International Agency for Research on Cancer (IARC) has identified Titanium Dioxide as a Group 2B Carcinogen - an agent that is “possibly carcinogenic” to humans but lacks sufficient human research.(1)
Looking ahead, the future of TiO2 industry factories appears poised for further advancement. Emerging trends such as the integration of nanotechnology and the exploration of alternative raw materials promise to revolutionize pigment properties and production processes. Additionally, the ongoing push for circular economy principles will likely result in increased recycling efforts within the industry, reducing reliance on virgin feedstocks and promoting a more sustainable business model.
As a supplier of lithopone for ink, it is important to maintain a consistent quality standard in order to meet the expectations of customers. This involves sourcing the pigment from reliable manufacturers, conducting thorough quality control checks, and ensuring that the product meets industry specifications and regulations.
Uses and benefits

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Furthermore, [Supplier Name] is committed to sustainability and environmental responsibility. We use eco-friendly production processes and source our raw materials from reputable suppliers to minimize our impact on the environment. As a responsible corporate citizen, we are dedicated to promoting sustainable development and contributing to a greener future.

Scrap zinc or concentrated zinc ores are dissolved in sulfuric acid, the solution is purified and the two solutions are reacted. A heavy mixed precipitate results that is 28 to 30% zinc sulfide and 72 to 70% barium sulfate.

In cosmetics, titanium dioxide’s properties enhance coloration and can help protect skin from damaging UVA and UVB rays.

Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive, commented Matthew Wright, member of the EFSA's Food Additives and Flavourings Panel in a press statement.
The lithopone factory in China plays a crucial role in the global pigment industry, providing high-quality products at competitive prices. While the industry faces challenges, the government's efforts to promote sustainable development and the increasing demand for eco-friendly products offer opportunities for growth. As the industry continues to evolve, it will be important for factories to adopt environmentally friendly practices and innovate to remain competitive in the global market.