- Another significant advantage of HPMC is its biocompatibility and safety profile. Being a non-toxic and non-allergenic material, it is generally recognized as safe (GRAS) by regulatory agencies for direct addition to food. This attribute makes HPMC a preferred choice for manufacturers who prioritize patient safety and adherence to stringent regulatory guidelines.
- Properties of HPMC
Seed coating:
JECFA (1990), the SCF (1994), the EFSA AFC Panel (2004) and the EFSA ANS Panel (2018) all considered it unnecessary to set an ADI for celluloses, including HPMC, based on a low toxicity and, if any, negligible absorption in the human gastrointestinal tract.
Hydroxypropyl Methylcellulose (HMPC) is a polysaccharide additive used in frosting, coatings, gluten-free baking and dietary supplements. It is also a stabilizer, thickener, fat replacer, bulking and binding agent. 1
Of course, there are plenty of other materials that supplement capsules can be made from. HPMC is by far the most common, but bovine gelatine capsules are still used occasionally, or there are more unusual options, such as pullulan, which is made from a tapioca extract.


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4. HPMC VS HEC : Dispersion
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