- The versatility of rutile type TiO2 extends to the field of cosmetics, where its non-toxic nature and ability to reflect UV light make it an ideal sunscreen ingredient. It is also utilized in food coloring due to its safety and efficacy in providing bright, appealing hues to food products.
It's also used in sunscreens as a UV filtering ingredient, helping to protect a person's skin by blocking absorption the ultraviolet light that can cause sunburn and cancer.
A review published in 2022 in the journal NanoImpact evaluated the latest research related to genotoxic effects of titanium dioxide through in vivo studies and in vitro cell tests. Researchers summarized the results by stating TiO2 nanoparticles “could induce genotoxicity prior to cytotoxicity,” and “are likely to be genotoxic to humans.”

Throughout the fourth quarter of 2021, the European market had consistent optimistic sentiment. Despite the overwhelming inventories at lower levels during the fourth quarter of 2021, the demand prognosis in the domestic market revealed varied opinions. Imports from the Asia Pacific region, on the other hand, remained disruptive due to limited accessibility of vessel freights and a decrease in the PMI index for titanium dioxide in China despite the application of severe environmental protection measures.
Lithopone 30% increases extruder performance and reduces processing costs, improves quality and is suitable for masterbatch for injection of Polyolefins, ABS, Polycarbonate, Polypropylene, Polyethylene, Polystyrene, single layer films, multi-layer films and for white, coloured and filled masterbatch. The combination of Lithopone 30 with TiO2 results in improved mechanical properties including higher elongation values and better impact resistance.
In a 2022 study published in the Journal of Hazardous Materials, scientists wanted to examine the effects of titanium dioxide as a food additive on atherosclerosis in mice. (Atherosclerosis refers to a hardening of the arteries.) Researchers fed mice 40 mg/kg of the food additive every day for 4 months, and found that it not only altered gut microbiota but also led to a significantly increased atherosclerotic lesion area, especially in animals that consumed a high-choline western diet (HCD).
The vitaminB2@TiO2NPs were obtained at room temperature, by a method developed after trying several ratios of reactants. Briefly, 0.02 g of P25TiO2NPs were dispersed in 1 mL of ultra-pure water and stirred in a Vortex. Next, 200 μl of vitamin B2 dissolved in ultra-pure water (5.3 × 10−3 M) were added to 200 μL of P25TiO2NPs and the mixture was ultrasonicated for 1 hour to achieve a deep-yellow homogeneous suspension. The pellet obtained after centrifuging the suspension for 10 min at 4500 rpm was resuspended in ultrapure water, centrifuged again, and then lyophilized.
Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.
Prof Matthew Wright, both a member of the FAF Panel and chair of EFSA’s working group on E 171, said: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”

In terms of manufacturers, there are many companies that produce calcium carbonate and titanium dioxide. Some of the top manufacturers of calcium carbonate include Omya, Imerys, and Minerals Technologies. These companies have large mining operations and production facilities in regions where calcium carbonate is abundant.
calcium carbonate vs titanium dioxide manufacturers

Journal Information
Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods our scientists could not rule out a concern for genotoxicity and consequently they could not establish a safe level for daily intake of TiO2 as a food additive.

As they mimic the synapses in biological neurons, memristors became the key component for designing novel types of computing and information systems based on artificial neural networks, the so-called neuromorphic electronics (Zidan, 2018; Wang and Zhuge, 2019; Zhang et al., 2019b). Electronic artificial neurons with synaptic memristors are capable of emulating the associative memory, an important function of the brain (Pershin and Di Ventra, 2010). In addition, the technological simplicity of thin-film memristors based on transition metal oxides such as TiO2 allows their integration into electronic circuits with extremely high packing density. Memristor crossbars are technologically compatible with traditional integrated circuits, whose integration can be implemented within the complementary metal–oxide–semiconductor platform using nanoimprint lithography (Xia et al., 2009). Nowadays, the size of a Pt-TiOx-HfO2-Pt memristor crossbar can be as small as 2 nm (Pi et al., 2019). Thus, the inherent properties of memristors such as non-volatile resistive memory and synaptic plasticity, along with feasibly high integration density, are at the forefront of the new-type hardware performance of cognitive tasks, such as image recognition (Yao et al., 2017). The current state of the art, prospects, and challenges in the new brain-inspired computing concepts with memristive implementation have been comprehensively reviewed in topical papers (Jeong et al., 2016; Xia and Yang, 2019; Zhang et al., 2020). These reviews postulate that the newly emerging computing paradigm is still in its infancy, while the rapid development and current challenges in this field are related to the technological and materials aspects. The major concerns are the lack of understanding of the microscopic picture and the mechanisms of switching, as well as the unproven reliability of memristor materials. The choice of memristive materials as well as the methods of synthesis and fabrication affect the properties of memristive devices, including the amplitude of resistive switching, endurance, stochasticity, and data retention time.
