In the paper industry, TiO2 is used to create high-quality, bright white paper products. By adding TiO2 to pulp, paper manufacturers can improve the opacity, brightness, and printability of their products. TiO2 also enhances the lightfastness and aging resistance of paper, ensuring that it maintains its appearance and quality over time. With TiO2, paper products can achieve a superior level of whiteness and visual appeal.

Because of its unique pigment and fine-milled texture, titanium dioxide has become popular over the past century in a wide variety of different products. These include adhesives, paints, plastics, rubbers, textiles, inks, ceramics, and even some pharmaceuticals, foods, and hygiene products.

A safety review conducted by the EFSA in 2021 assessed thousands of studies published on titanium dioxide.

In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone. 

The vitaminC@P25TiO₂NPs, on the other hand, were obtained through an optimized method based on Mallakpour et al. [27]. Initially, 0.02 g of P25TiO₂NPs were dispersed in 1 mL of ultrapure water and stirred in a Vortex. Next, 100 μL of HCl (0.01 M) were added (pH 2) to 100 uL of P25TiO₂NPs to avoid gel formation. Then, 100 μL of vitamin C dissolved in ultra-pure water (5.0 × 10⁻³ M) solution were added to the mixture and was ultrasonicated for 30 min. Finally, vitamin C was added in excess to gain a beige-orange color suspension, and the ultrasonication continued for another 30 min. The pellet obtained after centrifuging the suspension for 10 min at 4500 rpm was resuspended in ultrapure water, centrifuged again, and then lyophilized.

Suppliers of lithopone have recognized the growing need for high-quality, reliable products that meet both industry standards and consumer preferences. They have invested in advanced production techniques and stringent quality control measures to ensure that their lithopone products deliver consistent performance. This commitment to quality allows paint formulators to achieve the desired properties in their final products, such as enhanced durability, improved hiding power, and superior color stability over time.

This article discusses the discovery of phosphorescent lithopone on watercolor drawings by American artist John La Farge dated between 1890 and 1905 and the history of lithopone in the pigment industry in the late 19th and early 20th centuries. Despite having many desirable qualities for use in white watercolor or oil paints, the development of lithopone as an artists’ pigment was hampered by its tendency to darken in sunlight. Its availability to, and adoption by, artists remain unclear, as colormen's trade catalogs were generally not explicit in describing white pigments as containing lithopone. Further, lithopone may be mistaken for lead white during visual examination and its short-lived phosphorescence can be easily missed by the uninformed observer. Phosphorescent lithopone has been documented on only one other work-to-date: a watercolor by Van Gogh. In addition to the history of lithopone's manufacture, the article details the mechanism for its phosphorescence and its identification aided by Raman spectroscopy and spectrofluorimetry.

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After oral ingestion, the absorption of titanium dioxide particles is low, however they can accumulate in the body, Maged Younes, chair of the European Food Safety Authority's expert Panel on Food Additives and Flavourings, said in a May 2021 statement.